Use Caution/Keep an eye on. Ethinyl estradiol may well inhibit the clearance of benzodiazepines that endure oxidation, thus increasing serum concentrations of concomitantly administered benzodiazepines.
voriconazole will increase the stage or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Istradefylline 40 mg/day improved peak ranges and AUC of CYP3A4 substrates in medical trials. This influence wasn't noticed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.
drospirenone will raise the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
etravirine will reduce the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Almost every other medication that causes dizziness and sleepiness, like prescription soreness medicines, snooze medicines, and medicines for stress and anxiety
It has a presently accepted professional medical use in treatment method in The us. Abuse might bring about minimal Actual physical dependence or psychological dependence relative to Individuals in agenda 3.
Simply call your Health care company amongst visits as desired, particularly if that you are worried about indications. Suicidal feelings or steps may be because of items in addition to medicines. Should you have suicidal ideas or steps, your Health care company may get more info check for other triggers.
Lencapavir (a average CYP3A4 inhibitor) might increase CYP3A4 substrates initiated inside 9 months following past SC dose of lenacapavir, which may raise possible possibility of adverse reactions of CYP3A4 substrates.
fentanyl transdermal and diazepam both of those improve sedation. Avoid or Use Alternate Drug. Restrict use to patients for whom substitute treatment method solutions are inadequate
Doses of diazepam are advisable being about 50 percent of Those people provided to more youthful men and women, and remedy is limited to a utmost of two weeks. Lengthy-acting benzodiazepines which include diazepam will not be encouraged with the aged.[20] Diazepam can be hazardous in geriatric individuals owing to some substantially elevated risk of falls.[62]
Seizures. Having VALIUM with other medicines utilized to treat epilepsy could cause an increase in the number or severity of grand mal seizures.
Aged and very ill people can practical experience apnea or cardiac arrest. Concomitant utilization of other central anxious process depressants boosts this risk. The smallest possible powerful dose is normally utilized for this team of men and women.[60][61] The elderly metabolise benzodiazepines much more slowly but surely than more youthful Older people, and are much more sensitive to the effects of benzodiazepines, even at similar blood plasma concentrations.
lasmiditan, diazepam. Either boosts results of one other by sedation. Use Caution/Keep an eye on. Coadministration of lasmiditan together with other CNS depressant medicines, together with alcohol have not been evaluated in medical scientific tests. Lasmiditan might lead to sedation, and other cognitive and/or neuropsychiatric adverse reactions.